Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors

Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world. While the role of NSAIDs as cyclooxygenase (COX) inhibitors is well established, other targets may contribute to anti-inflammation. Here we report caspases as a new pharmacological target for NSAID family drugs such as ibuprofen, naproxen, and ketorolac at physiologic concentrations both in vitro...

Non-steroidal anti-inflammatory drugs.

[Non-steroidal anti-inflammatory drugs (NSAIDs)].

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[Non-steroidal anti-inflammatory drugs (NSAID)].

Various inflammatory diseases are currently treated with steroidal and non-steroidal anti inflammatory drugs

with steroidal and non-steroidal anti inflammatory drugs (NSAIDs). NSAIDs are drug with analgesic, antipyretic and in higher doses anti inflammatory effects. They inhibit synthesis of inflammation mediators. Most NSAIDs act as non-selective inhibitors of the enzyme cyclooxygenase (COX), by inhibiting the metabolism of arachidonic acid. COX catalyses the formation of prostaglandins (PGs) and thr...